Abstract: The retention mechanism in reversed-phase liquid chromatography was quantitatively described using log P (octanol-water partition coefficient). The hydrophobic (lipophilic) interaction liquid chromatography was then used to measure the hydrophobicity. Furthermore, a combination of log P and pKa...
Keywords: Hydrophobic; Liquid chromatography; MIES; MIHB
Special Issue Article “Crystallization”
Abstract: X-ray crystallography is the most efficient technique to decipher 3D structure of a protein at atomic resolution with high accuracy. Obtaining protein crystals is often considered the bottleneck of this technique...
Keywords: Membrane proteins; Detergents; Nucleation; Crystal growth; Thermodynamics; Optimization; Additives
Abstract: High performance liquid chromatographic method for determination of metformin in human plasma was developed. The method involved deproteinisation of the sample with methanol and analysis of the supernatant using Zorbax 300 – SCX, 4.6 X 150mm ID and UV detection at a wavelength of 233 nm...
Keywords: Tuberculosis; Anti-tuberculosis treatment; Diabetes mellitus; Metformin; Pharmacokinetics
Abstract: An accurate, rapid, selective and specific stability indicating RP-HPLC-UV method was developed for the simultaneous determination of Epalrestat and Pregabalin in combined pharmaceutical formulation. Chromatographic separation was achieved on Discovery ODS C18 column (250 × 4.6 mm, 5 μm)...
Keywords: Epalrestat; Pregabalin; Validation; Linearity
Special Issue Article “Two Dimensional Chromatography”
Abstract: The two-dimensional alignment of chromatograms remains the subject of ongoing research. The shift of a Sample chromatogram compared to a Reference chromatogram is a challenge to calculate, particularly when the interest lies in smaller signal peaks. Previous attempts include a variety...
Keywords: Curfit2D; Two-dimensional (2D) alignment; Warp function
Abstract: A reversed-phase high-performance liquid chromatographic method has been developed for the simultaneous quantitation of water-soluble vitamins like ascorbic acid (C), thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6) and folic acid (B9) in five potent wild edible plants...
Keywords: Wild edible plants; Water soluble vitamins; B group vitamins; Vitamin C; HPLC Analysis
Special Issue Article “Analytical Chromatography”
Abstract: The thermodynamic and acid base properties of some polymeric materials such as polylactides used in many industrial applications were determined by using the inverse gas chromatography technique at infinite dilution. Retention volume of the injected organic probes into the chromatographic...
Keywords: Free energy of Adsorption; Specific enthalpy and entropy; Lewis acid and base constants; Donor and acceptor number of electron; Glass transition; Hamieh’ s model
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