pharmacology@scientificliterature.org
A B S T R A C T
Background and objective: Saroglitazar magnesium, is indicated to treat patients with diabetic dyslipidemia. Saroglitazar achieves its purported activity via dual PPARαγ agonism, predominant PPARα activity. Its development was carried out with objectives of imparting dyslipidemic and anti-hyperglycaemic effects, and reducing the commonly reported side effects of PPAR modulators.
Keywords:
Saroglitazar; PPAR agonist; Gender effect; Pharmacokinetics; Diabetic dyslipidemia; Lipaglyn TM
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Mini Review
Physiological behavior of invasive hepatocellular carcinoma (HCC) is in the state of rapid division, aggressive growth and wide dispersion [1]. They are complicated with forming new blood vessels (angiogenesis) [2], separating from mother tumor (migration) and forming new tumor (metastasis).
Keywords:
Hepatocellular; DNA; TGFβ1; HBV; HCV
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Mini Review
Acute Liver Failure (ALF) after ingestion of overdosed paracetamol (syn. acetaminophen) can partially be prevented if N-Acetylcysteine (NAC) is early administered as a specific antidote to restore hepatic glutathione levels. These are reduced during paracetamol intoxication due to scavenging toxic intermediates generated through the metabolic action of hepatic microsomal Cytochrome P450
(CYP), preferentially its isoenzyme 2E1.
Keywords:
Acetaminophen, Paracetamol, Alcohol, Drug induced liver injury, Roussel Uclaf Causality Assessment, Method, Cytochrome P450 2E1
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OPINION PIECE
Pharmacological treatment for neuropathic pain is completely different from that for
nociceptive pain. Effective medicine and significance of pharmacological treatment
are different between the two pains.
Keywords:
Pharmacological therapy, Neuropathic pain, Fibromyalgia, Discontinuation criterion
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LETTER
In fact, an academic article is different from a clinical practice. Knowledge about the difference improves treatment outcomes. An academic article is based on scientific evidence and a clinical practice is based on personal experience of a physician. My specialty is a pharmacological treatment for pain [1-10] and the issue is discussed in the area.
Keywords:
Academic article, Clinical practice, Fibromyalgia, Neuropathic pain, Medication
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