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A B S T R A C T
Background and objective: Saroglitazar magnesium, is indicated to treat patients with diabetic dyslipidemia. Saroglitazar achieves its purported activity via dual PPARαγ agonism, predominant PPARα activity. Its development was carried out with objectives of imparting dyslipidemic and anti-hyperglycaemic effects, and reducing the commonly reported side effects of PPAR modulators.
Keywords:
Saroglitazar; PPAR agonist; Gender effect; Pharmacokinetics; Diabetic dyslipidemia; Lipaglyn TM
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Mini Review
Acute Liver Failure (ALF) after ingestion of overdosed paracetamol (syn. acetaminophen) can partially be prevented if N-Acetylcysteine (NAC) is early administered as a specific antidote to restore hepatic glutathione levels. These are reduced during paracetamol intoxication due to scavenging toxic intermediates generated through the metabolic action of hepatic microsomal Cytochrome P450
(CYP), preferentially its isoenzyme 2E1.
Keywords:
Acetaminophen, Paracetamol, Alcohol, Drug induced liver injury, Roussel Uclaf Causality Assessment, Method, Cytochrome P450 2E1
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ABSTRACT
Adrenergic drugs which bind to adrenergic receptors (α1, α2, β1, β2, β3) act as endogenous catecholamines secreted by the adrenal gland which constitute a “fight or
flight” response and are considered the first option in multiple life-threatening conditions. That is to say, these drugs are the mainstay of therapeutic algorithms in
Emergency Department (ED). Keywords:
Sympathomimetic toxicity, Sympathetic nervous system, Chronotropy, Dromotropy, Inotropy
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