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chromatography@scientificliterature.org
Occurrence of pharmaceutically active compounds in the environment is of great concern and has been the focus of an increasing number of recent studies. Although the use of pharmaceuticals has positive effects on treating many diseases in animals and humans, their improper use has become a new environmental problem. More than 600 pharmaceutical substances have been detected in different environmental matrices worldwide such as wastewater, surface water, ground water, soil and even drinking water [1].
The most commonly detected classes include human/veterinary antibiotics, hormones, non-steroidal anti-inflammatory drugs, central nervous system stimulants and antidepressants [1].
Abstract
Over the past decades, in vitro and in vivo permeation studies have been widely used in the pharmaceutical
area due to their ability to provide important pharmaceutical data for the rational development
of topical and transdermal delivery systems. In order to achieve success on topical or transdermal
therapy, the drug must be able to penetrate into the skin - a semi permeable barrier which
controls the entrance of molecules into the body.
Keywords
liquid chromatography; Anti-inflammatory drugs; Drug skin retained; Epidermis; Dermis; Permeation studies
Abstract
In this communication an attempt has been made to compare the two major classes of natural dyes-Anthraquinoid and Indigoid with their synthetic analog. Madder (Rubia cordifolia n Rubia tinctorum L.) and Indigo (Indigofera tinctoria) dyes were used for this study.
Keywords
Madder dye; Indigo dye; HPTLC; Imaging system; Densitometer; Chromatogram
Abstract
This paper describes a gas chromatography-mass spectrophotometry (GC-MS) method with selected-ion monitoring (SIM ) for the measurement of urine cocaine levels. Cocaine and codeine (internal standard, IS) were extracted from human urine with a mixture of diethylether and ethylacetate at basic pH with liquid-liquid extraction. Calibration curve was linear over the concentration range 50-2000 ng mL-1.
Keywords
Cocaine; GC-MS; Liquid-liquid extraction; Validation
Abstract
A HPLC method was developed for the simultaneous determination of six water-soluble vitamins, thiamine (B1), riboflavin (B2), nicotinic acid (B3), pyridoxine (B6), biotin (B7) and folic acid (B9) in milk, human urine and multivitamin pharmaceutical formulations.
Keywords
Cocaine; GC-MS; Liquid-liquid extraction; Validation