The Comparison of Antioxidative and Proliferation Inhibitor Properties of Fresh and Dried Piper betle L. Leave Extracts on MCF-7, Hela, and SK-LU-1 Cancer Cell Lines

This research aimed to identify the bioactive compounds present in dried and fresh betel leaf extracts. The cytotoxicity properties and antioxidant activity of the extracts were assessed in vitro. Gas chromatography–mass spectrometry is a method for identifying biologically compounds (GC–MS). The GC-MS analysis identified eugenol as the primary compound in dried betel leaves (37.56%), while 2.5-dimethylbenzoic aci...

ICER Report Further Justifies Gene Therapy for Sickle Cell Disease and Other Inherited Disorders

Recent report by the Institute for Clinical and Economic Review (ICER) [1], a clinical cost effectiveness watchdog based in the United States of America, provides further significant justification for health policy support in aid of Gene Therapy for Sickle Cell Disease (SCD) and similar inherited disease conditions. Sickle Cell Disease is an inherited (genetic) blood condition characterized by several debilitating...

Frailty in the COVID-19 Pandemic and the Potential of Stem Cells

The concept of frailty is common knowledge but it is a relatively new scientific discipline due its extensive study in the last two decades [1]. Measured in terms of the accumulation of deficits/ Frailty Index (FI) approach or the frailty phenotype/ syndromic approach, the results of frailty are adverse health outcomes and innumerable challenges to health care resources and health systems including emergency room...

Mesenchymal Stromal Cells in Novel COVID-19 Therapeutics

Coronavirus Disease 2019 (COVID-19) has already claimed over nine hundred thousand lives worldwide with more than twenty-eight million cases at present and increasing. Several research groups around the globe are working on developing therapeutics and vaccines to stall the pandemic. COVID-19 is caused by coronavirus SARS-CoV-2, and one of the major observations in COVID-19 patients is a drastic impact on the immun...

Guidelines for Assistance to Patients with Sickle Cell Disease in Front of Covid-19

Severe acute respiratory syndrome coronavirus 2, also known as COVID -19, has spread to more than 212 countries with almost 3.28 million cases as April 2020 since first reported [1,2]. The clinical features of this disease are not completely understood, however severe illness is thought to predominantly occur in adults with advanced age and those with underlying comorbidities [3]. Sickle Cell Disease (SCD), an imm...

An Oral Dose of Interferon Influences Creatine Kinase in Cattle

The purpose of a study was to determine the dose of natural bovine Interferon (IFN) given orally to calves to induce changes in the expression of genes associated with autoimmunity and inflammation as determined by Quantitative Polymerase Chain Reaction (qPCR) assays on RNAs isolated from Peripheral Blood Mononuclear Cells (PBMC). A study with IFN administered orally at 0, 50, 200 or 800 units per calf was conduct...

Generation of Hemangiogenic Progenitors from Human Embryonic Stem Cells

The close spatio-temporal relation during development between the hematopoietic and endothelial cells suggests the existence of a common progenitor of these two lineages, the hemangioblast. Since the isolation and characterization of this bipotent progenitor from chick embryos in 1920, many efforts had made in identifying the mouse and human equivalents, but they have been hampered by the difficult access to early...

State of Art on Idiosyncratic Drug-Induced Severe Neutropenia and Agranulocytosis

In this paper, we report and discuss the clinical impact of severe and acute neutropenia with the example of idiosyncratic drug-induced severe neutropenia and agranulocytosis (neutrophil count of

Review and Clinical Report Comparing Herbal Remedies and Stem-Cell Application to Chronic Leg Ulcers

Conventional treatments of leg ulcers includes repeated debridements, herbal dressings and interventions like split skin graftings. With adverse predisposing factors such as diabetes, aging and foot deformities, many ulcers fail to heal. For chronic ulcers of over 2 years duration, treatment was done by applying Mesenchymal Stem Cells derived from adipose tissues (MSC) directly into the ulcers: 4 cases of Chronic...