Abstract: Polysorbate 80 as a non-ionic surfactant has been widely used as a stabilizer for protein products to minimize interface induced degradation during manufacture and long-term storage. During manufacture of therapeutic proteins, polysorbate 80 is usually prepared in water as a stock solution...
Keywords: Polysorbate 80; Dissolution; UV-vis; SoloVPE; Biopharmaceuticals; Formulation; Manufacture
Abstract: This study describes as a single bout of physical exercise reduce plasma Asymmetric Dimethylarginine (ADMA) levels. ADMA is a naturally occurring aminoacid that aroused interest because inhibits Nitric Oxide Synthases (NOS) enhancing atherogenesis and producing sustained hypertensive...
Keywords: ADMA; DDAH; Physical exercise; Homocysteine; Nitric oxide
Abstract: The drug 5-Fluorouracil (5-FU) is used in various therapies as anti metabolic including several cancers and many skin diseases. In this work, we develop a bioanalytical method to quantify the 5-FU into the porcine ear skin samples after in vitro skin permeation studies by HPLC-UV...
Keywords: 5-Fluorouracil; Skin permeation; High-performance liquid chromatography; Opical application; Skin retention
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