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A B S T R A C T
Identification of the types of joint action of factors are considered on the basis of the response surface theory. On the example of the model of the full factorial experiment 22, the main effects model with interaction was investigated. It is shown that, within the framework of this model, there is an equivalence of the paradigms of dose additivity and effect additivity.
Keywords: Response surface methodology; Combined action; Effect additivity; Dose additivity; Isobole; Oppositely directed action
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A B S T R A C T
The SureID® 21G Human STR Identification kit, produced by Health Gene Technologies, is a next generation kit that amplifies 20 autosomal STR loci (including several CODIS and European Standard Set (ESS) loci) and the sex locus Amelogenin.The kit uses a fast- cycling PCR technology, which allows, in less than 2 hours, the amplification of 21 markers in a single multiplex assay using the 5-dye technology.
Keywords:
SureID® 21G, STRs, Validation, Reduced volumes, Direct PCR
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A B S T R A C T
Introduction: We have revised the steps of the sample sizes calculation for the biomedical research. Then, focusing on the agreement studies on qualitative variables we have shown the
derivation of the Cohen’s kappa together with the factors influencing its value, leading to have low kappa values even in presence of a relevant observed agreement. We
have revised the sample size calculation approaches for the Cohen’s kappa proposed in the statistical literature.
Keywords:
Raters’ agreement, Cohen’s kappa statistic, Sample sizes calculation
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